HIV and Cancer
WHat's the link between hiv and cancer?
Even when a person with HIV takes cART as prescribed and has an undetectable viral load, they are more likely to develop cancer than the general population.
AIDS DEFINING CANCERS
Kaposi Sarcoma, Non-Hodgkin Lymphoma, Cervical Cancer
AIDS-defining cancers are cancers that were seen at high rates in people with HIV at the beginning of the AIDS pandemic. If a person is diagnosed with one of these cancers, they are said to have AIDS. With the widespread use of cART, the incidence of these cancers in people with HIV has dropped.
NON-AIDS DEFINING CANCERS
Anal Cancer, Hodgkin Lymphoma, Lung Cancer, & others
Non-AIDS defining cancers are cancers that are now seen at higher rates in people with HIV due to aging as a result of increased life expectancy, co-infection with cancer-causing viruses like HPV and EBV, lifestyle risk factors like smoking, and immunosuppression.
HIV and CanceR
people with hiv have poorer cancer outcomes
Comparison of cancer treatment between HIV+ and HIV- patients. Treatment rates between HIV+ and HIV- were significantly different in all cancer types except anal cancer. Data from Suneja G, Lin CC, Simard EP, Han X, Engels EA, Jemal A. Disparities in cancer treatment among patients infected with the human immunodeficiency virus. Cancer. 2016 Aug 1;122(15):2399-407. doi: 10.1002/cncr.30052. Epub 2016 May 17. PMID: 27187086.
HIGHER MORTALITY Rates
Mortality rate per 1000 person years from patients in 6 U.S. states by gender. Reference group included patients without HIV and cancer. Data from Coghill, A. E., Pfeiffer, R. M., Shiels, M. S., & Engels, E. A. (2017). Excess Mortality among HIV-Infected Individuals with Cancer in the United States. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 26(7), 1027–1033. https://doi.org/10.1158/1055-9965.EPI-16-0964
We know the terminology used when discussing cancer and HIV is confusing.
Enter a word or phrase in the search box to the left and select search to find easy-to-understand definitions from the National Cancer Institute.
Hernández-Ramírez RU, Shiels MS, Dubrow R, Engels EA. Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage study. Lancet HIV. 2017 Nov;4(11):e495-e504. doi: 10.1016/S2352-3018(17)30125-X. Epub 2017 Aug 10. PMID: 28803888; PMCID: PMC5669995.